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Planta Med 2015; 81(04): 286-291
DOI: 10.1055/s-0035-1545696
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Protective Effect of Tetrahydrocurcumin against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies

Kyung Il Song   *
1   Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea
,
Jun Yeon Park   *
2   College of Korean Medicine, Gachon University, Seongnam, Korea
,
Seungyong Lee
3   Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea
4   Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea
,
Dahae Lee
2   College of Korean Medicine, Gachon University, Seongnam, Korea
4   Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea
,
Hyuk-Jai Jang
5   Department of Surgery, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea
,
Su-Nam Kim
3   Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea
,
Hyeonseok Ko
6   Laboratory of Molecular Oncology, Cheil General Hospital & Womenʼs Healthcare Center, Kwandong University College of Medicine, Seoul, Korea
,
Hyun Young Kim
4   Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea
,
Jae Wook Lee
3   Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea
,
Gwi Seo Hwang
2   College of Korean Medicine, Gachon University, Seongnam, Korea
,
Ki Sung Kang
2   College of Korean Medicine, Gachon University, Seongnam, Korea
,
Noriko Yamabe
2   College of Korean Medicine, Gachon University, Seongnam, Korea
› Author Affiliations
Further Information

Publication History

received 23 July 2014
revised 15 January 2015

accepted 16 January 2015

Publication Date:
26 February 2015 (online)

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Abstract

The adverse effects of anticancer drugs can prompt patients to end their treatment despite the efficacy. Cisplatin is a platinum-based molecule widely used to treat various forms of cancer, but frequent and long-term use of cisplatin is limited due to severe nephrotoxicity. In the present study, we investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage, oxidative stress, and inflammation to evaluate its possible use in renal damage. Cisplatin-induced LLC-PK1 renal cell damage was significantly reduced by tetrahydrocurcumin treatment. Additionally, the protective effect of tetrahydrocurcumin on cisplatin-induced oxidative renal damage was investigated in rats. Tetrahydrocurcumin was orally administered every day at a dose of 80 mg/kg body weight for ten days, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) in 0.9 % saline on day four. The creatinine clearance levels, which were markers of renal dysfunction, in cisplatin-treated rats were recovered nearly back to normal levels after administration of tetrahydrocurcumin. Moreover, tetrahydrocurcumin exhibited protective effects against cisplatin-induced oxidative renal damage in rats by inhibiting cyclooxygenase-2 and caspase-3 activation. These results collectively provide therapeutic evidence that tetrahydrocurcumin ameliorates renal damage by regulating inflammation and apoptosis.

Key words

cisplatin - nephrotoxicity - tetrahydrocurcumin - oxidative renal damage - COX-2

* These two authors contributed equally to the work described in this study.


 

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