Endoscopy 2015; 47(04): 345-348
DOI: 10.1055/s-0034-1390798
Case series
© Georg Thieme Verlag KG Stuttgart · New York

Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE), and neuromuscular and vascular hamartoma (NMVH): two sides of the same coin?

Lisa Setaffy
1   Institute of Pathology, Medical University, Graz, Austria
,
María José Martín Osuna
2   Institute of Pathology, Carlos Haya University Hospital, Malaga, Spain
,
Wolfgang Plieschnegger
3   Department of Internal Medicine, Hospital of Barmherzige Brüder, Academic Teaching Hospital, St. Veit/Glan, Austria
,
María del Pino Florez Rial
2   Institute of Pathology, Carlos Haya University Hospital, Malaga, Spain
,
Karel Geboes
4   Institute of Pathology, Ghent University Hospital, Ghent, Belgium
,
Cord Langner
1   Institute of Pathology, Medical University, Graz, Austria
› Author Affiliations
Further Information

Publication History

submitted 27 July 2014

accepted after revision 22 September 2014

Publication Date:
20 November 2014 (online)

Multifocal stenosing enteritis, not related to Crohn’s disease or drug intake, has been described under two different terms: “cryptogenic multifocal ulcerous stenosing enteritis” (CMUSE) and “neuromuscular and vascular hamartoma” (NMVH). We present three new cases of this condition and argue that the two terms reflect the same disease entity. Although etiology and pathogenesis of the disease remain largely unclear, obliterative vascular changes may play an important role.

 
  • References

  • 1 Fortun PJ, Hawkey CJ. Nonsteroidal antiinflammatory drugs and the small intestine. Curr Opin Gastroenterol 2007; 23: 134-141
  • 2 Debray C, Besancon F, Hardouin JP et al. Cryptogenetic plurifocal ulcerative stenosing enteritis. Arch Mal Appar Dig Mal Nutr 1964; 53: 193-206
  • 3 Perlemuter G, Guillevin L, Legman P et al. Cryptogenetic multifocal ulcerous stenosing enteritis: an atypical type of vasculitis or a disease mimicking vasculitis. Gut 2001; 48: 333-338
  • 4 Chang DK, Kim JJ, Choi H et al. Double balloon endoscopy in small intestinal Crohn’s disease and other inflammatory diseases such as cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). Gastrointest Endosc 2007; 66: 96-S98
  • 5 Fraile G, Norman F, Reguero ME et al. Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) in a man with a diagnosis of X-linked reticulate pigmentary disorder (PDR). Scand J Gastroenterol 2008; 43: 506-510
  • 6 Hussey S, Bourke B, Broderick A et al. Cryptogenic, multifocal, ulcerous, and stenosing enteritis as a manifestation of enterocolic venopathy. J Pediatr Gastroenterol Nutr 2008; 47: 107-109
  • 7 Kwon SO, Kim YS, Kim SY et al. A case of cryptogenic multifocal ulcerous stenosing enteritis: differential diagnosis from Crohn’s disease. J Gastrointestin Liver Dis 2012; 21: 309-312
  • 8 Fernando SS, McGovern VJ. Neuromuscular and vascular hamartoma of small bowel. Gut 1982; 23: 1008-1012
  • 9 Smith CE, Filipe MI, Owen WJ. Neuromuscular and vascular hamartoma of small bowel presenting as inflammatory bowel disease. Gut 1986; 27: 964-969
  • 10 Kwasnik EM, Tahan SR, Lowell JA et al. Neuromuscular and vascular hamartoma of the small bowel. Dig Dis Sci 1989; 34: 108-110
  • 11 Salas A, Casellas F, Sanz J et al. Neuromesenchymal hamartoma of the small bowel. J Clin Gastroenterol 1990; 12: 705-709
  • 12 Scintu F, Capra F, Giordano M et al. Neuromuscular and vascular hamartoma of the small intestine. Report of a clinical case and review of the literature. Chir Ital 2001; 53: 393-398
  • 13 Theodosiou E, Voulalas G, Salveridis N et al. Neuromesenchymal hamartoma of small bowel – an extremely rare entity: a case report. World J Surg Oncol 2009; 7: 92
  • 14 Kaplan JL, Goldstein AM, Shenoy-Bhangle A et al. Neuromuscular and vascular hamartoma of the small intestine in a child. J Pediatr Gastroenterol Nutr 2013; 56: e33-e35
  • 15 Freeman HJ. Multifocal stenosing ulceration of the small intestine. World J Gastroenterol 2009; 15: 4883-4885
  • 16 Shepherd NA, Jass JR. Neuromuscular and vascular hamartoma of the small intestine: is it Crohn’s disease?. Gut 1987; 28: 1663-1668
  • 17 Shelley-Fraser G, Borley NR, Warren BF et al. The connective tissue changes of Crohn’s disease. Histopathology 2012; 60: 1034-1044