Synthesis 2015; 47(10): 1447-1454
DOI: 10.1055/s-0034-1380278
paper
© Georg Thieme Verlag Stuttgart · New York

An Efficient, Mild, Solvent-Free, One-Pot Three-Component Mannich Reaction Catalyzed by (C4H12N2)2[BiCl6]Cl·H2O

Hongfei Lu*
a   School of Environment and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, P. R. of China   Email: zjluhf1979@hotmail.com
,
Runze Wu
a   School of Environment and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, P. R. of China   Email: zjluhf1979@hotmail.com
,
Helong Cheng
a   School of Environment and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, P. R. of China   Email: zjluhf1979@hotmail.com
,
Shipeng Nie
a   School of Environment and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, P. R. of China   Email: zjluhf1979@hotmail.com
,
Yan Tang
a   School of Environment and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, P. R. of China   Email: zjluhf1979@hotmail.com
,
Yuhua Gao
a   School of Environment and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, P. R. of China   Email: zjluhf1979@hotmail.com
,
Zhibin Luo*
b   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212003, P. R. of China   Email: zhibinluo@hotmail.com
› Author Affiliations
Further Information

Publication History

Received: 18 November 2014

Accepted after revision: 06 February 2015

Publication Date:
06 March 2015 (online)


Abstract

An efficient and practical method for the one-pot Mannich reaction of aromatic ketones with aldehydes and amines at room temperature has been developed under solvent-free conditions catalyzed by (C4H12N2)2[BiCl6]Cl·H2O (3 mol%). The catalyst may also be recycled multiple times by simple isolation protocols without compromising the catalytic efficiency.

Supporting Information

 
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