Synlett 2012; 23(10): 1489-1492
DOI: 10.1055/s-0031-1290670
letter
© Georg Thieme Verlag Stuttgart · New York

A Modular, Stereoselective Approach to Spiroketal Synthesis

Michael T. Crimmins*
,
Adam M. Azman
Further Information

Publication History

Received: 10 February 2012

Accepted after revision: 30 March 2012

Publication Date:
29 May 2012 (online)


Abstract

A highly convergent and flexible synthetic approach to stereochemically defined spiroketals is reported. Substituents can be incorporated at various positions around the spiroketal framework without significant disruption to the synthetic scheme. The approach has been exploited to prepare the spiroketal fragment of milbemycin β14.

Supporting Information

 
  • References

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