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Skull Base Rep 2011; 1(1): 065-070
DOI: 10.1055/s-0031-1275638
© Thieme Medical Publishers

Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)

Andrew P. Carlson1 , Howard Yonas1 , Garth T. Olson2 , Kaaren K. Reichard3 , Rafael Medina-Flores3
  • 1Department of Neurological Surgery, University of New Mexico, Albuquerque, New Mexico
  • 2Division of Otolaryngology, Department of Surgery, University of New Mexico, Albuquerque, New Mexico
  • 3Department of Pathology, University of New Mexico, Albuquerque, New Mexico
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Publication History

Publication Date:
25 March 2011 (online)

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ABSTRACT

The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblastoma: a rare, benign but locally invasive chondroid tumor. Genetic testing revealed a translocation of (2;5) (q33;q13). This is a unique genetic mutation in all chondroid tumors to our knowledge. The diagnostic utility or role of this mutation in the pathobiology of this tumor remains to be determined.

KEYWORDS

Chondroblastoma - genetics - karyotype - temporal bone - skull-base tumor - cytogenetics

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Rafael Medina-FloresM.D. 

Department of Pathology, MSC08-4640

1 University of New Mexico, Albuquerque, NM 87131

Email: rmedina-flores@salud.unm.edu

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