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DOI: 10.1055/s-0030-1251733
NMR Based Screening Tool for Quality Control of Botanical Dietary Supplements
Assessment of quality of botanical dietary supplements is challenging due to the complex nature of the molecular components that vary with growing location, seasonal conditions, harvesting conditions and processing conditions. The ability of NMR to analyze complex mixtures as a non-targeted fingerprinting method combined with rapid sample preparation makes it an attractive analytical tool for the routine analysis of botanical extracts. In this presentation we will show our work towards developing an NMR based quality control tool for crude botanical extracts including grape seed, pine bark, skullcap, ginseng, cranberry and blueberry. This presentation includes (1) evaluation of NMR reproducibility between different instruments and different operators to establish robust screening methods, (2) statistical methods used to characterize the botanical extracts, (3) sample characterization to provide information such as the varietal, sample purity, and natural variation in samples, and (4) identification of the presence of single components within a crude extract and quantification of these components.