Synthesis of 1,4-Disubstituted 1,2,3-Triazoles by Use of Copper(I) and Amino Acids Ionic Liquid Catalytic System

 

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Abstract

An efficient and green one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from aryl iodides and alkyl chlorides, sodium azide, and terminal alkynes catalyzed by copper(I) and amino acid ionic liquid (AAIL) in [BMIM]BF₄ was developed. The reactions proceeded smoothly to generate the corresponding products in high yields. In addition, CuI, AAIL, and [BMIM]BF₄ could be recovered for six consecutive trials without significant loss of activity.

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