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Exp Clin Endocrinol Diabetes 1993; 101(5): 307-310
DOI: 10.1055/s-0029-1211249
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Effect of L-Thyroxine and Carbimazole on Blood Levels of Biogenic Amines in Rat

L. Upadhyaya1 , J. K. Agrawal1 , G. P. Dubey2
  • 1Division of Endocrinology Department of Medicine, Varanasi, India
  • 2Centre of Psychosomatic and Biofeedback Medicine of Institute of Medical Sciences Banaras Hindu University, Varanasi, India
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Publication History

Publication Date:
15 July 2009 (online)

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Summary

Circulating levels of 5-hydroxytryptamine (5HT), histamine, monoamine oxidase (MAO), histaminase, tri-iodothyronine (T3) and thyroxine (T4) were studied in L-thyroxine and carbimazole treated rats. Increased concentrations of 5-HT, histamine, glutamate, T3 and T4 were recorded in L-thyroxine-treated rats while plasma gamma-aminobutyric acid (GABA), MAO and histaminase levels were significantly decreased. Considerable reduction in 5-HT, glutamate, T3 and T4 with trend towards the rise in plasma levels of MAO and histaminase was noticed in carbimazole treated group. There was a significant correlation between these amines and thyroid hormone values. The findings suggest that alterations in the metabolism of thyroid hormones may have a link with the altered metabolism of biogenic amines.

Key words

Biogenic amines - L-thyroxine - Carbimazole - Thyroid hormones

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