Dtsch Med Wochenschr 2020; 145(09): 601-608
DOI: 10.1055/a-0983-0349
Dossier

Pathologisch-genetisch orientierte Diabetes-Reklassifizierung

Reclassification of diabetes mellitus based on pathophysiologic and genetic features
Robert Wagner
,
Andreas Fritsche

Abstract

Diabetes mellitus has been defined by hyperglycemia, but in addition to hyperglycemia, there are several other factors determining the clinical course and complications. We review the current classification of diabetes and recent attempts to identify new subphenotypes. Notably, there are anthropometry-pathophysiology based and genome-based subphenotyping approaches. They aim to improve the prediction of disease course and complications and could pave the way for precision medicine in the therapy of diabetes.

Die pathologisch-genetisch orientierte Reklassifizierung des Diabetes-Krankheitsspektrums liefert die Basis für eine Präzisionsmedizin, deren Konzept eine auf den einzelnen Patienten zugeschnittene Therapie zum Ziel hat. Die unterschiedlichen Subphänotypen des Diabetes mellitus könnten durch Präzisionsmedizin wahrscheinlich besser behandelt werden. Entsprechende Einteilungen wurden nun vorgelegt.



Publication History

Article published online:
29 April 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 
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