Planta Med 2008; 74 - P-103
DOI: 10.1055/s-2008-1075299

Phytochemical Investigation of Dryopteriscrassirhizoma Nakai

Z Gao 1, 3, J Zhao 3, Z Ali 3, L Qiao 2, H Lei 1, Y Lu 1, IA Khan 3, 4
  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China
  • 2Pekjing University, Health Science Center, Beijing, 100083, China
  • 3National Center for Natural Products Research, University of Mississippi, MS 38677, USA
  • 4Department of Pharmacognosy, School of Pharmacy,University of Mississippi, MS 38677, USA

The pharmacological activities of the rhizome and leftover petiole of Dryopteris crassirhizoma Nakai include anti-tumor, anti-bacterial, anti-virus, and anti-malarial activities [1–5]. It is a traditional Chinese medicine to cure flu and verminosis and recorded in Chinese pharmacopoeia named Mianma Guanzhong in Chinese [6]. A comprehensive phytochemical investigation of chemical constituents of rhizome of D. crassirhizoma resulted in the isolation of 18 compounds, including two new, [2R,3R]-2,3-cis-3,5,7,3ʹ,5ʹ-pentahydroxyflavan-8-C-α -glucopyranoside (1) and trisflavaspidic acid ABB (2). The structures of isolates were established by spectral and chemical methods. Acknowledgements: Thanks to China Scholarship Council for funding assistance. References: [1] Li Dehua, Hao Xiaoge, Xue Weijian. (1986) Zhong Cao Yao, 17(6): 14. [2] Zheng Minshi, Han Yiping. (1988) Yao Xue Tong Bao 23(4): 234. [3] Zhu Lijiang. (1996) Zhong Guo Zhong Yi Yao Xin Xi Za Zhi 3(3): 17. [4] Dong Jiede. (1993) Journal of Shan Dong College of Traditional Chinese Medicine 17(4): 46. [5] Gao Zengping, Lu Yunru, Jiang Peifen. (2002) Journal of Beijing University of Traditional Chinese Medicine 25(4): 45. [6] The pharmacopoeia Commission of P. R. China. (2005) The Pharmacopoeia of P. R. China I: 231.