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Synfacts 2008(1): 0011-0011  
DOI: 10.1055/s-2007-992392
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Pederin

Contributor(s): Philip Kocienski, Zofia Komsta
J. C. Jewett, V. H. Rawal*
University of Chicago, USA
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

Pederin is present in the haemo­lymph of the rove beetles of the Paederus genus. It exhibits a broad range of interesting biological properties, including nanomolar activity against tumor cells. This short and relatively efficient synthesis features a highly diastereoselective construction of the pyranone ring C via a Mukaiyama aldol cyclization.