Ru(II)-Catalyzed Asymmetric Ring-Closing Metathesis

T. W. Funk; J. M. Berlin; R. H. Grubbs

doi:10.1055/s-2006-934346

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Synfacts 2006(5): 0455-0455
DOI: 10.1055/s-2006-934346

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Ru(II)-Catalyzed Asymmetric Ring-Closing Metathesis

Contributor(s): Mark Lautens, Andrew Martins
T. W. Funk, J. M. Berlin, R. H. Grubbs*
California Institute of Technology, Pasadena, USA

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Publication History

Publication Date:
21 April 2006 (online)

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Significance

The desymmetrization of a variety of trienes was accomplished via asymmetric ring-closing metathesis using chiral Ru-based olefin metathesis catalysts. Enantioselectivity and yields are generally good, affording synthetically useful chiral building blocks.