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Planta Med 2006; 72(1): 84-86
DOI: 10.1055/s-2005-873184
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Two New Abietane Diterpenoids from Salvia yunnanensis

Gang Xu1 , 2 , Li-Yan Peng1 , Lei Lu3 , Zi-Ying Weng1 , Yu Zhao1 , Xiao-Li Li1 , Qin-Shi Zhao1 , Han-Dong Sun1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China
  • 3Guiyang Medical College
Further Information

Publication History

Received: April 10, 2005

Accepted: June 20, 2005

Publication Date:
10 November 2005 (online)

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Abstract

Two new abietane diterpenoids, yunnannin A (1) and danshenol C (2), were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A (3), przewalskin (4), tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds 1 - 3 were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound 3 showed inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines while compound 2 was inactive. Compound 1 showed moderate inhibitory activity on QGY (IC50 = 16.75 μg/mL) and Me180 (IC50 = 5.84 μg/mL) cells.

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Prof. Dr. Qin-Shi Zhao

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

Heilongtan

Kunming 650204

People’s Republic of China

Phone: +86-871-522-3254

Fax: +86-871-521-6317

Email: qinshizhaosp@ yahoo.com

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