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Planta Med 2004; 70(6): 578-581
DOI: 10.1055/s-2004-827164
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Two New Coumarin Derivatives from the Roots of Heracleum rapula

Xue-Mei Niu1 , Sheng-Hong Li1 , Li-Xin Wu2 , Ling Li3 , Li-Hui Gao3 , Han-Dong Sun1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 2Guiyang Medical College, Guiyang, Guizhou, P. R. China
  • 3Yunnan Pharmacological Laboratory of Natural Products, Kunming Medical College, Kunming, Yunnan, P. R. China
This project was supported by grants from the National Natural Science Foundation of China (No. 30 200 349), the Natural Science Foundation of Yunnan Province (No. 2002C0017Q), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province (No. 2003RC07, awarded to Dr. Sheng-Hong Li)
Further Information

Publication History

Received: November 19, 2003

Accepted: March 7, 2004

Publication Date:
01 July 2004 (online)

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Abstract

Two new coumarins, 13-O-[β-D-apiofuranosyl(1→6)-β-D-glucopyranosyl]-(12R)-heraclenol (1) and (12R,12′′R)-diheraclenol (2) were isolated from the acetone extract of the fresh roots of Heracleum rapula. Their structures were determined by means of spectroscopic analysis and, in the case of compound 1, the structure elucidation was supported by acid hydrolysis. Compound 1 is a coumarin glycoside while 2 is a coumarin dimer. The inhibitory effects of 1, its aglycone (3), and 2 on rabbit platelet aggregation induced by PAF, AA and ADP were tested. Weak activities were observed for each compound with the percentages of inhibition in the range of 0.7 - 24.8 %.

References

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Dr. Shenghong Li

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

The Chinese Academy of Sciences

Heilongtan

Kunming 650204

Yunnan Province

People's Republic of China

Fax: +86-871-5216343

Email: shli@mail.kib.ac.cn

Email: hdsun@mail.kib.ac.cn

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