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Planta Med 2002; 68(10): 946-948
DOI: 10.1055/s-2002-34926
Letter
© Georg Thieme Verlag Stuttgart · New York

ent-Kaurane Diterpenoids from the Leaves of Isodon xerophilus

Sheng-Hong Li1 , Xue-Mei Niu1 , Li-Yan Peng1 , Hong-Jie Zhang2 , Ping Yao2 , Han-Dong Sun1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, Yunnan, P. R. China
  • 2Program for Collaborative Research in the Pharmaceutical sciences, College of Pharmacy, University of Illinois at Chicago, 833 Wood Street, Chicago, Illinois, USA
Further Information

Publication History

Received: January 10, 2002

Accepted: June 1, 2002

Publication Date:
21 October 2002 (online)

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Abstract

From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1 - 3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were isolated and structurally elucidated. Compound 6 demonstrated most potent cytotoxic activity against K562 and T24 human tumor cell lines with IC50 = 0.09 and 0.32 μg/ml, respectively.

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Prof. Dr. Han-Dong Sun

State Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

The Chinese Academy of Sciences

Heilongtan

Kunming 650204

Yunnan Province

People’s Republic of China

Email: hdsun@mail.kib.ac.cn

Fax: +86 871 5216343

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