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Journal of Pediatric Neurology 2007; 05(03): 233-238
DOI: 10.1055/s-0035-1557390
DOI: 10.1055/s-0035-1557390
Case report
Diffusion-tensor imaging in stem cell transplantation associated microangiopathy
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Further Information
Publication History
18 March 2007
27 March 2007
Publication Date:
30 July 2015 (online)
Abstract
We describe changes in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in tacrolimus associated encephalopathy. ADC was clearly increased and FA decreased in the involved regions. There was a strong local contrast-enhancing effect along the cortical surface. Repeat magnetic resonance imaging five days later showed an increase in FA; but no contrast enhancement. The observed ADC and FA changes in the acute phase suggest that vasogenic edema may play a pivotal role in tacrolimus induced neurotoxicity. The contrast-effect can be explained by disturbed venous drainage caused by thrombotic microangiopathy.