Planta Med 2014; 80 - PC33
DOI: 10.1055/s-0034-1382415

New polyketides from a freshwater Lindgomycetaceae sp.

ND Paguigan 1, HA Raja 1, T El-Elimat 1, NH Oberlies 1
  • 1Department of Chemistry and Biochemistry, University of North Carolina, Greensboro, NC 27402 – 6170, USA

Freshwater fungi remain to be an under-explored source of secondary metabolites with a high probability of discovering new structures that may be used as potential drug leads. Thus, our group has been interested in the chemical diversity of compounds produced by freshwater fungi (Ascomycetes) collected in North Carolina. In the course of this undertaking, seven new structurally-related polyketides, lindgomycin A-G (1 – 7) were isolated from an organic extract of a freshwater Lindgomycetaceae sp. (G416). Compound 6 was a homodimer of 1, while 7 was a heterodimer of the monomeric units of 1 and 2. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR (1H, 13C, HSQC, and HMBC) and HRMS data.