Planta Med 2012; 78 - PI195
DOI: 10.1055/s-0032-1320883

Cytotoxic withanolide constituents of Physalis longifolia

H Zhang 1, A Samadi 2, R Gallagher 1, JJ Araya 1, HF Motiwala 1, K Kindscher 3, R Gollapudi 1, MS Cohen 2, J Aubé 1, BN Timmermann 1
  • 1Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA
  • 2Department of Surgery, University of Kansas Medical Center, Kansas, KS 66160, USA
  • 3Kansas Biological Survey, University of Kansas, Lawrence, KS 66047, USA

Twenty three withanolides including sixteen new 1-16 (named as withalongolides A-P) were isolated from the aerial parts of Physalis longifolia Nutt. (Solanaceae). Their structures were elucidated through spectroscopic techniques including X-ray crystallography (for 1-3, 6, and 15). Nine withanolides and six derivatives showed potent cytotoxicity against a panel of cells (JMAR, MDA-1986, B16F10, DR081–1, SKMEL-28, Hs578T, and MRC-5) with IC50 values in the range of 0.067 ˜ 17.4µM.