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Synfacts 2011(10): 1128-1128
DOI: 10.1055/s-0030-1261117
DOI: 10.1055/s-0030-1261117
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Organocatalytic Enantioselective Fluorocyclizations
O. Lozano, G. Blessley, T. Martinez del Campo, A. L. Thompson, G. T. Giuffredi, M. Bettati, M. Walker, R. Borman, V. Gouverneur*
University of Oxford and GlaxoSmithKline R&D, Stevenage, UK
Further Information
Publication History
Publication Date:
20 September 2011 (online)
Significance
The first successful catalytic process, which delivers enantioenriched fluorinated heterocyclic products upon fluorocyclization of prochiral precursors has been developed by Gouverneur and co-workers. Both mono- and difluorinated cyclization products (3 and 4) were obtained under different conditions. According to NMR studies, it is the N-fluoroammonium salt of the alkaloid which may be responsible for the enantiocontrol in the reaction.