Total Synthesis of Chloptosin

A. J. Oelke; D. J. France; T. Hofmann; G. Wuitschik; S. V. Ley

doi:10.1055/s-0030-1258880

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Synfacts 2010(12): 1333-1333
DOI: 10.1055/s-0030-1258880

Synthesis of Natural Products and Potential Drugs

Total Synthesis of Chloptosin

Contributor(s): Steven V. Ley, Catherine F. Carter
A. J. Oelke, D. J. France, T. Hofmann, G. Wuitschik, S. V. Ley*
University of Cambridge, UK

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Publication History

Publication Date:
22 November 2010 (online)

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Significance

Chloptosin was isolated from a culture broth of Streptomyces by Umezawa et al. It induces apoptosis in several apoptosis-sensitive cancer cell lines and displays antimicrobial activity.