Antileishmanial Germacranolides from Calea zacatechichi

 

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Abstract

Phytochemical study of the leaves and stems of Calea zacatechichi Schl. (Asteraceae) led to the isolation of a series of six germacranolides (1–6) with significant antileishmanial activity. The structure of a new compound named by us as calealactone D (1) was determined by NMR and MS, and its absolute configuration by X‐ray crystallography. In addition, calealactone E (5) was discovered as a new naturally occurring compound, and the absolute configuration of calealactone C (2) was also determined by X‐ray crystallography. All compounds were biologically evaluated in antimicrobial and antiprotozoal assays.

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Prof. Dr. Jordan K. Zjawiony

Department of Pharmacognosy and Research Institute of Pharmaceutical Sciences
School of Pharmacy
University of Mississippi

University MS 38677-1848

USA

Phone: +16 6 29 15 79 20

Fax: +16 6 29 15 69 75

Email: jordan@olemiss.edu

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