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Synthesis 2010(6): 1046-1052  
DOI: 10.1055/s-0029-1218629
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Nucleoside Conjugates as Potential Inhibitors of Glycogen Phosphorylase

Keguang Chenga,b, Jun Liuc, Hongbin Sun*b, Juan Xie*a
a PPSM, ENS Cachan, Institut d’Alembert, CNRS, Universud, 61 av. Président Wilson, 94230 Cachan, France
Fax: +33(1)47402454; e-Mail: joanne.xie@ens-cachan.fr;
b Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P. R. of China
Fax: +86(25)83271198; e-Mail: hbsun2000@yahoo.com;
c Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P. R. of China
Further Information

Publication History

Received 9 November 2009
Publication Date:
04 January 2010 (online)

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Abstract

Click chemistry has been successfully used for the synthesis of novel nucleoside conjugates between uridine and N-acetylglucosamine or oleanolic acid derivatives. These molecules displayed micromolar inhibition towards glycogen phosphorylase.

Key words

bioorganic chemistry - carbohydrates - click chemistry - inhibitors - nucleosides

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