Synthesis of FD-594 Aglycon

R. Masuo; K. Ohmori; L. Hintermann; S. Yoshida; K. Suzuki

doi:10.1055/s-0029-1217860

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Synfacts 2009(10): 1064-1064
DOI: 10.1055/s-0029-1217860

Synthesis of Natural Products and Potential Drugs

Synthesis of FD-594 Aglycon

Contributor(s): Philip Kocienski, Zofia Komsta
R. Masuo, K. Ohmori, L. Hintermann, S. Yoshida, K. Suzuki*
Tokyo Institute of Technology, Japan

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Publication History

Publication Date:
22 September 2009 (online)

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Significance

FD-594 is an antitumor antibiotic isolated from Streptomyces sp. TA-0256. A high-yielding first total synthesis of its aglycon is presented. The key step of the synthesis is the diastereoselective pinacol cyclization of axially chiral biaryl aldehyde D.