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Synfacts 2009(10): 1128-1128  
DOI: 10.1055/s-0029-1217850
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Asymmetric Enyne Cycloisomerization

Contributor(s): Mark Lautens, David A. Candito
K. C. Nicolaou*, A. Li, S. P. Ellery, D. J. Edmonds
The Scripps Research Institute, La Jolla and University of California, San Diego, USA
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

The authors report the rhodium-catalyzed asymmetric enyne cycloisomerization reaction of terminal alkynes and apply this methodology to the formal total synthesis of (-)-platensimycin. A key to the success of their catalyst system is the use of a well-defined rhodium complex.