Largamides A–C, Tiglic Acid-Containing Cyclodepsipeptides with Elastase-Inhibitory Activity from the Marine Cyanobacterium Lyngbya confervoides

 

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Abstract

Three unusual tiglic acid-containing cyclodepsipeptides, possessing the revised regioisomeric structures for largamides A – C (1–3), have been isolated from the marine cyanobacterium Lyngbya confervoides collected from southeastern Florida. The two-dimensional structures were determined by NMR spectroscopy and the absolute configurations by chiral HPLC analysis of degradation products. Compounds 1–3 are moderate inhibitors of mammalian elastase activity in vitro with IC₅₀ values ranging from 0.53 to 1.41 µM.

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Prof. Dr. Hendrik Luesch

Department of Medicinal Chemistry
University of Florida

1 600 SW Archer Road

Gainesville

Florida 32610

USA

Phone: + 1 35 22 73 77 38

Fax: + 1 35 22 73 77 41

Email: luesch@cop.ufl.edu

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