NEWS AND REVIEWSGalanin and spinal nociceptive mechanisms: recent advances and therapeutic implications
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Increased neuropeptide Y (NPY)-like immunoreactivity in rat sensory neurons following peripheral axotomy
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Intra-periaqueductal gray injection of galanin increases the nociceptive response latency in rats, an effect reversed by naloxone
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The N-terminal 1–16, but not C-terminal 17–29, galanin fragment affects the flexor reflex in rats
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Intrathecal galanin blocks the prolonged increase in spinal cord flexor reflex induced by conditioning stimulation of unmyelinated muscle afferents in the rat
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M-15, high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus and spinal cord
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M35 and M40 distinguish between the putative galanin receptor subtypes
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Cited by (87)
Organization of the galaninergic neuronal system in the brain of the gecko Hemidactylus frenatus
2023, NeuropeptidesCitation Excerpt :Additionally, the present study reveals bundles of GAL-ir fibres running rostrocaudally along the RAI and ventral funiculus. Although the spinal cord receives projections from the brain stem and is involved in modulation of pain and other somatosensory functions in reptiles and mammals (Cruce, 1975; ten Donkelaar et al., 1980; Xu et al., 2000), we did not notice any perikarya in the brain stem or spinal cord in the gecko brain. Therefore, further neuronal tracing studies are required to understand the significance of GAL-ir fibres in the spinal cord in reptiles.
The neuropeptide galanin modulates natural killer cell function
2017, NeuropeptidesCitation Excerpt :The neuropeptide galanin shows a widespread distribution in both the central and peripheral nervous systems (Lang et al., 2015). Its role in non-neuronal cells is poorly understood, nevertheless it has been demonstrated that, during inflammation, peripheral tissues (e.g. the skin) produce and release galanin (Bauer et al., 2008; Kofler et al., 2004; Xu et al., 2000). Immune cells as well express galanin, and increased expression levels have been observed in several animal models of inflammation (Ji et al., 1995; Lang and Kofler, 2011).
Expression and release of progalanin in fibroblasts
2014, Regulatory PeptidesCitation Excerpt :Three galanin receptors, GAL1 [24], GAL2 [25], and GAL3 [26], are expressed in the central and peripheral nerve systems. In the peripheral tissue, galanin is involved in axotomy [27–29] and chronic nerve compression [30,31], and peripheral nerve injury [32] induces increased galanin expression in dorsal root ganglion neurons. In the peripheral tissue, some nonneural cells also express a galanin-like immunoreactive component (galanin-LI), including the nerve terminals and fibers of the dermis [33], keratinocytes [34,35], follicular and interfollicular epidermal cells, ductal cells of the eccrine sweat glands [33,34], and fibroblast-like cells during granulation [36].
Galanin and Receptors
2009, Encyclopedia of NeuroscienceNeuropeptides: Pain
2009, Encyclopedia of Neuroscience