Original ArticleHigh Left Ventricular Filling Pressure on Doppler Echocardiography Is Associated With Graft Failure and Overall Mortality Following Kidney Transplantation
Section snippets
Study Population
This retrospective study evaluated all patients who underwent KT between January 2006 and December 2013 at the authors’ institution. In total, 1,348 patients who underwent KT initially were included in the study population. Of these 1,348 patients, 303 patients were excluded, including 9 patients who were<18 years old, 135 patients with missing data on the E/e′, 19 patients with valvular heart disease, and 140 patients who underwent cadaveric KT. The study protocol was approved by the
Results
The median follow-up duration for the general patient population was 3.4 years (interquartile range: 1.7-5.5 years). Of 1,045 patients, 821 patients (78.6%) had an E/e´<15 (10.1±2.3), and 224 patients (21.4%) had an E/e´≥15 (18.6±4.0). Patients with an E/e′≥15 were older and had higher BMI and lower albumin and sodium levels. Moreover, patients with E/e′≥15 demonstrated higher incidences of diabetes, hypertension, coronary artery disease, cerebrovascular accident, and use of β-blockers and
Discussion
In the authors’ present study, they confirmed that an E/e´≥15 was associated with overall mortality in ESRD patients following KT. In addition, they found that an E/e´≥15 was associated with graft failure and postoperative hemodialysis. Notably, the authors’ current results showed that increased morbidity and mortality were sustained even after IPTW adjustment, indicating that the E/e´ measure was independently associated with mortality in ESRD patients following KT.
It generally is accepted
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2020, Revista da Associacao Medica Brasileira