Regular ArticleMRI of Creutzfeldt–Jakob Disease: Imaging Features and Recommended MRI Protocol
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Clinical diagnosis of human prion disease
2020, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Cortical high signal change is also seen. In vCJD, the key diagnostic feature is high signal in the posterior thalamus (the “pulvinar sign”).5 It is important to note that the “pulvinar sign” is not simply high signal in that region (which may be seen in sCJD) but higher signal there relative to what is seen in other areas of the brain.
Prion Problem: A Rapidly Progressive Dementia
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2019, NeuroImage: ClinicalVariant Creutzfeldt–Jakob disease
2018, Handbook of Clinical NeurologyCitation Excerpt :The disease hallmark is the so-called pulvinar sign, consisting of high signal in the posterior thalamus. Other areas may be involved, such as the dorsomedial thalamic nuclei and the periaqueductal gray matter (Collie et al., 2001, 2003; Summers et al., 2002). It is important to note that high signal may also be seen in the caudate and putamen in vCJD (areas that are characteristically involved in sCJD), but the pulvinar sign, as defined, consists of signal intensity that is higher in the posterior thalamus than in any other area such as the anterior basal ganglia.
Sporadic Creutzfeldt–Jakob disease
2018, Handbook of Clinical Neurology
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Author for correspondence and guarantor of study: Dr D. A. Collie, Department of Neuroradiology, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, U.K.