Original ContributionsInflammatory pseudotumors of the central nervous system: Report of 3 cases and a literature review☆
Section snippets
Patients and methods
Detailed clinical records were available for the 3 patients with IP-CNS who had been treated at the University Hospital RWTH Aachen between 1996 and 2001. One patient was suffering from an additional pulmonary IP. To begin, 7-μm-thick sections from formalin-fixed and paraffin-embedded tissue specimens were stained for hematoxylin and eosin and Elastica-van Gieson according to routine methods. Immunohistochemistry was also performed according to routine methods with peroxidase/DAB or alkaline
Patient 1
In this boy, a left thoracic IP had necessitated left-sided pneumonectomy at age 2 years. Six years later he suffered a right-sided seizure due to a round, calcified non-contrast-enhanced lesion within the left temporal lobe. During surgery, a solid, not well-delineated tumor infiltrating the surrounding brain tissue was found and resected incompletely. After surgery, no radiation or chemotherapy was performed. Postsurgical magnetic resonance imaging (MRI) revealed a small residual left
Discussion
IP-CNS represent a diagnostic and clinical challenge. Due to their nonspecific neuroradiologic and clinical findings,4 the correct diagnosis depends on the postsurgical histopathologic examinations and on the pathologist's awareness of this rare disease. The possibility of IP should be considered in all intracranial tumor-like lesions composed of a lymphoplasmacellular infiltrate and a collagenous stroma of varying density, regardless of additional features such as giant cells, calcifications,
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2019, World NeurosurgeryCitation Excerpt :IMT in the central nervous system (IMT-CNS) is rare, and usually shows a female predominance with a wide age range (mostly affects children and young adults).8,9 The clinical symptoms of IMT-CNS are nonspecific and imageological features are protean.5 Therefore, the diagnosis of IMT predominately depends on histopathologic and immunostaining analysis.
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