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Scanning mass spectrometry probe for biochemical imaging

Scanning mass spectrometry probe for biochemical imaging

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© The Institution of Engineering and Technology
Published

A novel ion source concept for sampling and ionising molecules for mass spectrometric analysis which is amenable for integration with an atomic force microscope is described. This combination enables simultaneous imaging of the topography of complex biological samples as well as their local biochemical make-up. The resulting scanning mass spectrometry probe has potential to become a new tool for spatially and temporally resolved, in-situ mass spectrometric analysis of biological tissues or even a single cell.

Inspec keywords: atomic force microscopy; cellular biophysics; mass spectroscopy; biomedical imaging; biochemistry; biological techniques; biological tissues

Other keywords: biological cells; biological tissues; scanning mass spectrometry probe; atomic force microscope; biochemical imaging; biochemical make-up

Subjects: Cellular biophysics; Molecular biophysics; Biophysical instrumentation and techniques; Biomedical measurement and imaging; Mass spectrometry (chemical analysis)

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