Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires’ disease in humans, a severe atypical pneumonia. The pathogen encodes six peptidylprolyl cis–trans isomerases (PPIases), which generally accelerate folding of prolyl peptide bonds, and influence protein folding. PPIases can be divided into three classes, cyclophilins, parvulins and FK506-binding proteins (FKBPs). They contribute to a multitude of cellular functions including bacterial virulence. In the present review, we provide an overview of L. pneumophila PPIases, discussing their known and anticipated functions as well as moonlighting phenomena. By taking the example of the macrophage infectivity potentiator (Mip) of L. pneumophila, we highlight the potential of PPIases as promising drug targets.
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December 2014
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Conference Article|
November 17 2014
Peptidylprolyl cis–trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets
Janine Rasch;
Janine Rasch
*Institut für Mikrobiologie, Technische Universität Braunschweig, 38106 Braunschweig, Germany
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Can M. Ünal;
Can M. Ünal
*Institut für Mikrobiologie, Technische Universität Braunschweig, 38106 Braunschweig, Germany
†Fen Fakültesi, Türk-Alman-Üniversitesi, 34820, Istanbul, Turkey
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Michael Steinert
Michael Steinert
1
*Institut für Mikrobiologie, Technische Universität Braunschweig, 38106 Braunschweig, Germany
‡Helmholtz Centre for Infection Research, 38124, Braunschweig, Germany
1To whom correspondence should be addressed (emailm.steinert@tu-bs.de).
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Publisher: Portland Press Ltd
Received:
July 23 2014
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2014 Biochemical Society
2014
Biochem Soc Trans (2014) 42 (6): 1728–1733.
Article history
Received:
July 23 2014
Citation
Janine Rasch, Can M. Ünal, Michael Steinert; Peptidylprolyl cis–trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets. Biochem Soc Trans 1 December 2014; 42 (6): 1728–1733. doi: https://doi.org/10.1042/BST20140202
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