Issue 0, 1984

Afromontoside. A new cytotoxic principle from Dracaena afromontana

Abstract

A new cytotoxic principle, steroidal saponin afromontoside (1), has been isolated from a methanolic extract of the twigs of Dracaena afromontana. It was shown to be (25R)-furost-5-ene-3β,22α,26-triol 26-O-α-L-rhamnopyranoside 3-O-([O-α-L-rhamnopyranosyl(1→4)]-β-D-glucopyranoside) by spectral and chemical methods. The aglycone of afromontoside, diosgenin, as well as dihydrodiosgenin and several structurally related compounds have been shown to be cytotoxic to cultured KB cells.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1984, 987-992

Afromontoside. A new cytotoxic principle from Dracaena afromontana

K. S. Reddy, M. S. Shekhani, D. E. Berry, D. G. Lynn and S. M. Hecht, J. Chem. Soc., Perkin Trans. 1, 1984, 987 DOI: 10.1039/P19840000987

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