Issue 44, 2023
From the journal:

Nanoscale

Hollow Cu2−xSe-based nanocatalysts for combined photothermal and chemodynamic therapy in the second near-infrared window†

Qianqian Gao,‡a   Xuelu He,‡a   Lulu He,‡ac   Jie Lin,abc   Le Wang,ac   Yujiao Xie,ac   Aiguo Wu ORCID logo *abc  and  Juan Li ORCID logo *abc  

* Corresponding authors

a Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Cixi Institute of Biomedical Engineering, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, China

b University of Chinese Academy of Sciences, Beijing 100049, P. R. China

c Advanced Energy Science and Technology Guangdong Laboratory, Huizhou, China

Abstract

Chemodynamic therapy (CDT) and photothermal therapy (PTT) have gained popularity due to their non-invasive characteristics and satisfying therapeutic expectations. A Cu-based nanomaterial serving as a Fenton-like nanocatalyst for CDT together with a photothermal agent for simultaneous PTT seems to be a powerful strategy. In this work, the morphological effect of Cu2−xSe nanoparticles on CDT and PTT was systematically investigated. In particular, the hollow octahedral Cu2−xSe nanoparticles exhibited higher photothermal and chemodynamic performance than that of spherical or cubic Cu2−xSe nanoparticles in the second near-infrared (NIR-II) window. In addition, the octahedral Cu2−xSe nanoparticles were further loaded with the autophagy inhibitor chloroquine (CQ) and connected with the targeting neuropeptide Y ligand, and shown to work as a novel therapeutic platform (Cu2−xSe@CQ@NPY), holding an immense potential to achieve synergetic enhancement of CDT/PTT with a positive therapeutic outcome for breast cancer.

Graphical abstract: Hollow Cu2−xSe-based nanocatalysts for combined photothermal and chemodynamic therapy in the second near-infrared window

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Article information

DOI
https://doi.org/10.1039/D3NR03260D
Article type
Paper
Submitted
05 Jul 2023
Accepted
22 Sep 2023
First published
13 Oct 2023

Nanoscale, 2023,15, 17987-17995

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Hollow Cu2−xSe-based nanocatalysts for combined photothermal and chemodynamic therapy in the second near-infrared window

Q. Gao, X. He, L. He, J. Lin, L. Wang, Y. Xie, A. Wu and J. Li, Nanoscale, 2023, 15, 17987 DOI: 10.1039/D3NR03260D

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