Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo

Didar Baimanov; Liming Wang; Ke Liu; Mengmeng Pan; Rui Cai; Hao Yuan; Wanxia Huang; Qingxi Yuan; Yunlong Zhou; Chunying Chen; Yuliang Zhao

doi:10.1039/D3NH00124E

Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo†

Didar Baimanov,

‡^ab Liming Wang,

‡^a Ke Liu,‡^ac Mengmeng Pan,^b Rui Cai,^a Hao Yuan,^a Wanxia Huang,^d Qingxi Yuan,^d Yunlong Zhou,

*^b Chunying Chen

*^aef and Yuliang Zhao*^aef

Author affiliations

* Corresponding authors

^a CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: chenchy@nanoctr.cn, zhaoyl@nanoctr.cn

^b Engineering Research Center of Clinical Functional Materials and Diagnosis &Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, P. R. China
E-mail: zhouyl@ucas.ac.cn

^c College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Sichuan province, Chengdu 610059, P. R. China

^d Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China

^e GBA Research Innovation Institute for Nanotechnology, Guangzhou 510700, Guangdong, P. R. China

^f Research Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China

Abstract

It is unknown how the identity provided by protein coronas on the surface of chiral nanoparticles determines their blood circulation, distribution, and clearance fates of the nanoparticles in vivo. Here, we attempt to investigate how the mirrored surface of gold nanoparticles with distinct chirality reshapes the coronal composition that mediates their subsequent clearance from blood and biodistribution. We found that chiral gold nanoparticles exhibited surface chirality-specific recognition for the coronal components, including the lipoproteins, complement components, and acute phase proteins, ultimately resulting in distinct cell uptake and tissue accumulation in vivo. We observed that these stereoselective behaviors were correlated to subgroups of the corona composition that could bind to low-density lipoprotein receptors. Therefore, this study reveals how chirality-specific protein compositions selectively recognize and interact with cell receptors for chirality-mediated tissue accumulation. This study will deepen our understanding of how chiral nanoparticles/nanomedicine/nanocarriers interact with biological systems to guide the efficient fabrication of target nanomedicines.

This article is part of the themed collections: Nanoscale Horizons HOT Papers, Celebrating the 20th anniversary of the National Center for Nanoscience and Technology (NCNST), 2024 Lunar New Year Collection and Nanoscale Horizons Most Popular 2023 Articles

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Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo†

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