Issue 7, 2023
From the journal:

RSC Medicinal Chemistry

Discovery and development of novel substituted monohydrazides as potent antifungal agents†

Nishad Thamban Chandrika,‡a   Keith D. Green,‡a   Abbygail C. Spencer,a   Oleg V. Tsodikov ORCID logo a  and  Sylvie Garneau-Tsodikova ORCID logo *a  

* Corresponding authors

a Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, USA
E-mail: sylviegtsodikova@uky.edu

Abstract

Novel substituted monohydrazides synthesized for this study displayed broad-spectrum activity against various fungal strains, including a panel of clinically relevant Candida auris strains. The activity of these compounds was either comparable or superior to amphotericin B against most of the fungal strains tested. These compounds possessed fungistatic activity in a time-kill assay and exhibited no mammalian cell toxicity. In addition, they prevented the formation of fungal biofilms. Even after repeated exposures, the Candida albicans ATCC 10231 (strain A) fungal strain did not develop resistance to these monohydrazides.

Graphical abstract: Discovery and development of novel substituted monohydrazides as potent antifungal agents

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Article information

DOI
https://doi.org/10.1039/D3MD00167A
Article type
Research Article
Submitted
10 Apr 2023
Accepted
30 May 2023
First published
14 Jun 2023

RSC Med. Chem., 2023,14, 1351-1361

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Discovery and development of novel substituted monohydrazides as potent antifungal agents

N. Thamban Chandrika, K. D. Green, A. C. Spencer, O. V. Tsodikov and S. Garneau-Tsodikova, RSC Med. Chem., 2023, 14, 1351 DOI: 10.1039/D3MD00167A

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