Issue 12, 2024

Pd(ii)-Catalyzed enantioselective C–H olefination toward the synthesis of P-stereogenic phosphinamides

Abstract

P-Stereogenic phosphorus compounds are important structural elements in chiral ligands or organocatalysts. Herein, we report a Pd(II)-catalyzed enantioselective C–H olefination toward the synthesis of P-stereogenic phosphinamides using cheap commercially available L-pGlu-OH as a chiral ligand. A broad range of P-stereogenic phosphinamides were gained in good yields with high enantioselectivities (33 examples, up to 77% yield, 99% ee) via desymmetrization and kinetic resolution.

Graphical abstract: Pd(ii)-Catalyzed enantioselective C–H olefination toward the synthesis of P-stereogenic phosphinamides

Supplementary files

Article information

Article type
Communication
Submitted
14 Oct 2023
Accepted
09 Jan 2024
First published
12 Jan 2024
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 1623-1626

Pd(II)-Catalyzed enantioselective C–H olefination toward the synthesis of P-stereogenic phosphinamides

Z. Chen, L. Fan, P. Xie, P. Qian, X. Hu, T. Zhou and B. Shi, Chem. Commun., 2024, 60, 1623 DOI: 10.1039/D3CC05052A

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