Issue 93, 2023

A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation

Abstract

An NAD+ featuring an adenosyl 4′-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.

Graphical abstract: A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2023
Accepted
29 Oct 2023
First published
03 Nov 2023

Chem. Commun., 2023,59, 13843-13846

A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation

E. N. Stephens, X. Zhang, A. T. Lam, J. Li, H. Pei, S. G. Louie, C. C. C. Wang and Y. Zhang, Chem. Commun., 2023, 59, 13843 DOI: 10.1039/D3CC04343F

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