Issue 76, 2023
From the journal:

Chemical Communications

Photocatalysed C–H amidation of indoles enabled by tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate†

Ke-yi Deng,‡a   Zhi-wei Wang,‡a   Zhen-zhen Xie,a   Jun-tao He,a   Jian-ping Guan,a   Kai Chen, ORCID logo a   Hao-yue Xiang ORCID logo *ab  and  Hua Yang ORCID logo *a  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China
E-mail: 215064@csu.edu.cn, hyangchem@csu.edu.cn

b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, Henan, P. R. China

Abstract

Development of a new catalytic and straightforward strategy to construct C–N bonds is playing a pivotal role in synthetic chemistry. Here, we report a photocatalysed protocol to access direct C–H amidation of indoles, enabled by a rationally designed tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate. A series of biologically important aminoindoles were prepared under mild conditions with excellent regioselectivity and broad substrate scope.

Graphical abstract: Photocatalysed C–H amidation of indoles enabled by tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate

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Article information

DOI
https://doi.org/10.1039/D3CC03532H
Article type
Communication
Submitted
23 Jul 2023
Accepted
28 Aug 2023
First published
05 Sep 2023

Chem. Commun., 2023,59, 11401-11404

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Photocatalysed C–H amidation of indoles enabled by tert-butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate

K. Deng, Z. Wang, Z. Xie, J. He, J. Guan, K. Chen, H. Xiang and H. Yang, Chem. Commun., 2023, 59, 11401 DOI: 10.1039/D3CC03532H

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