Issue 63, 2023
From the journal:

Chemical Communications

Construction of unsymmetrical heterobiaryls via the Cp*Rh(iii)-catalysed C–H/C–H coupling of heteroarenes†

Diksha Parmar,ab   Tamanna Sharma,a   Akhilesh K. Sharma ORCID logo *c  and  Upendra Sharma ORCID logo *ab  

* Corresponding authors

a C–H Activation & Phytochemistry Lab, Chemical Technology Division, CSIR-IHBT, Palampur 176061, India
E-mail: upendra@ihbt.res.in, upendraihbt@gmail.com

b Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India

c Institute of Chemical Research of Catalonia (ICIQ-CERCA), The Barcelona Institute of Science and Technology, Av. Països Catalans, 16, Tarragona 43007, Spain
E-mail: aksharma@iciq.es

Abstract

Herein, a concise method for the Rh(III)-catalyzed, directing-group-assisted C–H/C–H cross-coupling of N-heterocycles (quinolines, indolines, indoles, pyridines, pyrimidines, pyrazoles) with other heteroarenes (benzoxazoles, benzofurans, and thiophenes) is disclosed for the synthesis of unsymmetrical heterobiaryl compounds in good to excellent yields. A plausible catalytic cycle has been delineated based on experimental and computational mechanistic studies.

Graphical abstract: Construction of unsymmetrical heterobiaryls via the Cp*Rh(iii)-catalysed C–H/C–H coupling of heteroarenes

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Article information

DOI
https://doi.org/10.1039/D3CC03166G
Article type
Communication
Submitted
30 Jun 2023
Accepted
10 Jul 2023
First published
10 Jul 2023

Chem. Commun., 2023,59, 9646-9649

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Construction of unsymmetrical heterobiaryls via the Cp*Rh(III)-catalysed C–H/C–H coupling of heteroarenes

D. Parmar, T. Sharma, A. K. Sharma and U. Sharma, Chem. Commun., 2023, 59, 9646 DOI: 10.1039/D3CC03166G

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