Issue 61, 2023
From the journal:

Chemical Communications

Thermoresponsive hydrogel for transcatheter arterial chemoembolization of hepatocellular carcinoma†

Wei Zhao,‡a   Jiabin Xu,‡a   Yuanyuan You,b   Zhenhu Guo, ORCID logo c   Yun Xiang,a   Kenan Hao,a   Xiaofeng He*a  and  Peng Zhao ORCID logo *b  

* Corresponding authors

a Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
E-mail: ozonetherapy@126.com

b NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
E-mail: smuzp@smu.edu.cn

c State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, China

Abstract

Transarterial chemoembolization (TACE) is one of the most commonly used treatments for hepatocellular carcinoma (HCC); however, the poor stability of emulsified chemotherapy drugs by iodinated oil always leads to serious systemic cytotoxicity. Herein, a composite hydrogel Epi/Etpoil@MC/XG was proposed by stably distributing ethiodized poppyseed oil (Etpoil) and epirubicin (Epi) in the blend hydrogel of methylcellulose (MC) and xanthan gum (XG). Benefiting from its adjusted thermo-responsive and injectable properties, the Epi/Etpoil@MC/XG has been successfully applied in the embolization of the feeding artery for a VX2 tumor model.

Graphical abstract: Thermoresponsive hydrogel for transcatheter arterial chemoembolization of hepatocellular carcinoma

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Article information

DOI
https://doi.org/10.1039/D3CC02257A
Article type
Communication
Submitted
09 May 2023
Accepted
27 Jun 2023
First published
30 Jun 2023

Chem. Commun., 2023,59, 9352-9355

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Thermoresponsive hydrogel for transcatheter arterial chemoembolization of hepatocellular carcinoma

W. Zhao, J. Xu, Y. You, Z. Guo, Y. Xiang, K. Hao, X. He and P. Zhao, Chem. Commun., 2023, 59, 9352 DOI: 10.1039/D3CC02257A

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