Ti3C2 nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress

Hongqi Geng; Yaping Ren; Gang Qin; Tao Wen; Quan Liu; Haiyan Xu; Weiwei He

doi:10.1039/D2RA01225A

Ti₃C₂ nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress†

Hongqi Geng,^ab Yaping Ren,^b Gang Qin,^a Tao Wen,

*^c Quan Liu,^b Haiyan Xu

^c and Weiwei He

*^b

Author affiliations

* Corresponding authors

^a School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, P. R. China
E-mail: heweiweixcu@gmail.com

^b Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, College of Chemical and Materials Engineering, Institute of Surface Micro and Nano Materials, Xuchang University, Xuchang, Henan 461000, P. R. China

^c Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, P. R. China
E-mail: went@ibms.pumc.edu.cn

Abstract

Redox regulation in biological systems represents a fascinating method for treatment and prevention of oxidative stress induced diseases. The key and difficult point is to find ideal materials with excellent antioxidant capability and good biocompatibility. To this end, ultra-thin two-dimensional MXene (Ti₃C₂) nanosheets (NSs) were investigated for their antioxidant capability. It is found that Ti₃C₂ NSs can scavenge efficiently reactive oxygen and nitrogen species (˙OH, H₂O₂, Image ID:d2ra01225a-t1.gif and ˙NO), ABTS⁺˙ and DPPH˙ free radicals in a concentration dependent manner, showing broad-spectrum antioxidant activities. Ti₃C₂ NSs exhibit higher antioxidant activity and broader antioxidant capability than natural antioxidant molecules. The significant role of PEG modified Ti₃C₂ with good stability in preventing cell damage against oxidative stress was demonstrated. Upon treatment of H₂O₂ induced oxidative stress with Ti₃C₂, the intracellular ROS level decreases and the cell survival rate increases significantly. An antioxidant mechanism based on gradient oxidation was proposed to account for the superior antioxidant activity of Ti₃C₂. Our result proves that ultra-thin MXenes as antioxidants have great potential in preventing oxidative stress caused biological damage.

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Article information

DOI: https://doi.org/10.1039/D2RA01225A
Article type: Paper
Submitted: 23 Feb 2022
Accepted: 05 Apr 2022
First published: 08 Apr 2022
This article is Open Access

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RSC Adv., 2022,12, 11128-11138

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Ti₃C₂ nanosheets with broad-spectrum antioxidant activity for cytoprotection against oxidative stress

H. Geng, Y. Ren, G. Qin, T. Wen, Q. Liu, H. Xu and W. He, RSC Adv., 2022, 12, 11128 DOI: 10.1039/D2RA01225A

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