Issue 36, 2022

One-pot three-component access to 5-hydroxyindoles based on an oxidative dearomatization strategy

Abstract

A one-pot three-component reaction based on an oxidative dearomatization strategy has been performed to provide facile access to 5-hydroxyindole derivatives through a ZnI2-catalyzed tandem process. The multi-unit reactions for the construction of a new C–C bond and two C–N bonds are simple and efficient under mild conditions, and the yield of the target product is as high as 91%.

Graphical abstract: One-pot three-component access to 5-hydroxyindoles based on an oxidative dearomatization strategy

Supplementary files

Article information

Article type
Communication
Submitted
10 May 2022
Accepted
26 Aug 2022
First published
29 Aug 2022

Org. Biomol. Chem., 2022,20, 7241-7244

One-pot three-component access to 5-hydroxyindoles based on an oxidative dearomatization strategy

H. Qiu, L. Tong, Z. Lin, Z. Li, H. Ren, T. Wang and X. Yu, Org. Biomol. Chem., 2022, 20, 7241 DOI: 10.1039/D2OB00884J

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