The strategy of precise targeting and in situ oxygenating for enhanced triple-negative breast cancer chemophototherapy

Manxiang Wu; Tianxiang Chen; Lianfu Wang; Ozioma Udochukwu Akakuru; Xuehua Ma; Jinshan Xu; Jiapeng Hu; Jia Chen; Qianlan Fang; Aiguo Wu; Qiang Li

doi:10.1039/D2NR00985D

The strategy of precise targeting and in situ oxygenating for enhanced triple-negative breast cancer chemophototherapy†

Manxiang Wu,‡^abc Tianxiang Chen,‡^bc Lianfu Wang,^a Ozioma Udochukwu Akakuru,^bc Xuehua Ma,

^bc Jinshan Xu,^a Jiapeng Hu,^bcd Jia Chen,^e Qianlan Fang,^bc Aiguo Wu

*^bc and Qiang Li

*^a

Author affiliations

* Corresponding authors

^a Department of Radiology, The Affiliated People's Hospital of Ningbo University, Ningbo, China
E-mail: rmliqiang@nbu.edu.cn

^b Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 Zhongguan West Road, Ningbo 315201, P. R. China
E-mail: aiguo@nimte.ac.cn

^c Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, P.R. China

^d University of Chinese Academy of Sciences, Beijing, PR China

^e School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China

Abstract

The absence of effective therapeutic targets and tumor hypoxia are the main causes of failure in the treatment of triple-negative breast cancer (TNBC). Biomimetic nanotechnology and tumor microenvironment (TME) responsiveness bring hope and opportunity to address this problem. Here, we develop a core membrane nanoplatform (HM/D-I-BL) using hollow mesoporous manganese dioxide (HM) coated with a biomimetic cancer cell membrane for enhanced chemotherapy/phototherapy via the strategy of precise drug delivery and hypoxia amelioration. Cancer cell membrane modification endows HM/D-I-BL with excellent homologous targeting and immune escape performance. Cellular uptake and fluorescence imaging studies confirmed that HM/D-I-BL can be accurately delivered to tumor sites. HM/D-I-BL also features efficient in situ O₂ generation in tumors upon laser irradiation, and subsequently enhanced chemotherapy/phototherapy, pointing to its usefulness as a TME-responsive nanozyme to alleviate tumor hypoxia in the presence of H₂O₂. In addition, HM/D-I-BL showed good fluorescence and magnetic resonance imaging performances, which offers a reliable multimodal image-guided combination tumor therapy for precision theranostics in the future. In general, this intelligent biomimetic nanoplatform with its homotypic tumor targeting, in situ alleviation of tumor hypoxia and synergetic chemophototherapy would open up a new dimension for the precision treatment of TNBC.

Nanoscale

The strategy of precise targeting and in situ oxygenating for enhanced triple-negative breast cancer chemophototherapy†

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The strategy of precise targeting and in situ oxygenating for enhanced triple-negative breast cancer chemophototherapy

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