Issue 10, 2023

The molecular-level effect of alkoxide additives in iron-catalyzed Kumada cross-coupling with simple ferric salts

Abstract

The molecular-level role of alkoxide salts, used as alternative additive to N-methylpyrrolidone in iron-catalyzed alkyl–alkenyl/aryl cross-coupling reactions, is investigated. Detailed spectroscopic studies reveal that alkoxides promote the formation of homoleptic organoferrates such as [FeMe3], providing an alternative to toxic NMP to access these reactive intermediates.

Graphical abstract: The molecular-level effect of alkoxide additives in iron-catalyzed Kumada cross-coupling with simple ferric salts

Supplementary files

Article information

Article type
Communication
Submitted
18 Nov 2022
Accepted
03 Jan 2023
First published
03 Jan 2023

Chem. Commun., 2023,59, 1317-1320

The molecular-level effect of alkoxide additives in iron-catalyzed Kumada cross-coupling with simple ferric salts

N. J. Bakas, P. Chourreu, E. Gayon, G. Lefèvre and M. L. Neidig, Chem. Commun., 2023, 59, 1317 DOI: 10.1039/D2CC06257G

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