AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

Shengnan Liu; Jiahong Han; Yulei Chang; Weijin Wang; Runlin Wang; Ziwei Wang; Guangzhe Li; Dongxia Zhu; Martin R. Bryce

doi:10.1039/D2CC03622C

AIE-active iridium(iii) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy†

Shengnan Liu,

‡^a Jiahong Han,‡^a Yulei Chang,

*^b Weijin Wang,^a Runlin Wang,^a Ziwei Wang,^a Guangzhe Li,*^c Dongxia Zhu

*^a and Martin R. Bryce

*^d

Author affiliations

* Corresponding authors

^a Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China
E-mail: zhudx047@nenu.edu.cn

^b State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin Province 130033, China
E-mail: yuleichang@ciomp.ac.cn

^c Jilin Provincial Science and Technology Innovation Center of Health Food of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, Jilin Province 130117, P. R. China
E-mail: 1993008106@qq.com

^d Department of Chemistry, Durham University, Durham, UK
E-mail: m.r.bryce@durham.ac.uk

Abstract

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high ¹O₂ generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro. This work has potential for future photodynamic therapy (PDT) applications.

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DOI: https://doi.org/10.1039/D2CC03622C
Article type: Communication
Submitted: 29 Jun 2022
Accepted: 11 Aug 2022
First published: 22 Aug 2022
This article is Open Access

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Chem. Commun., 2022,58, 10056-10059

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AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

S. Liu, J. Han, Y. Chang, W. Wang, R. Wang, Z. Wang, G. Li, D. Zhu and M. R. Bryce, Chem. Commun., 2022, 58, 10056 DOI: 10.1039/D2CC03622C

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Chemical Communications

AIE-active iridium(iii) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy†

Abstract

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AIE-active iridium(III) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

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