Issue 21, 2022
From the journal:

Chemical Communications

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones†

Rui Fu,a   Yu Liu,a   Tao Wu,a   Xinyu Zhang,a   Yang Zhu,a   Jiangbin Luo,b   Zhengyu Zhanga  and  Yaojia Jiang ORCID logo *ab  

* Corresponding authors

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China
E-mail: iamyjjiang@njtech.edu.cn

b Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China

Abstract

This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.

Graphical abstract: Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

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Article information

DOI
https://doi.org/10.1039/D2CC00169A
Article type
Communication
Submitted
10 Jan 2022
Accepted
09 Feb 2022
First published
12 Feb 2022

Chem. Commun., 2022,58, 3525-3528

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Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

R. Fu, Y. Liu, T. Wu, X. Zhang, Y. Zhu, J. Luo, Z. Zhang and Y. Jiang, Chem. Commun., 2022, 58, 3525 DOI: 10.1039/D2CC00169A

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