Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids

Yue Cao; Shenghua Han; Han Zhang; Jie Wang; Qiao-Yan Jiang; Yimin Zhou; You-Jia Yu; Jianfang Wang; Feng Chen; Dennis K. P. Ng

doi:10.1039/D1TB01274F

Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids†

Yue Cao,

^ab Shenghua Han,^b Han Zhang,^c Jie Wang,^a Qiao-Yan Jiang,^a Yimin Zhou,

^b You-Jia Yu,^a Jianfang Wang,

^c Feng Chen

*^a and Dennis K. P. Ng

*^b

Author affiliations

* Corresponding authors

^a Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
E-mail: fchen@hjmu.edu.cn

^b Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
E-mail: dkpn@cuhk.edu.hk

^c Department of Physics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China

Abstract

A nanoprobe based on polydopamine-coated gold nanobipyramids surface modified with molecules of a phenylboronic acid-substituted distyryl boron dipyrromethene has been fabricated and characterised using various physical and spectroscopic methods. It serves as an ultrasensitive sensor for sialic acids on the surface of cancer cells based on its dual surface-enhanced Raman scattering and fluorescence response. This biomarker can also trigger the photodynamic activity of these nanobipyramids, effectively eradicating the cancer cells mainly through apoptosis as shown by various bioassays.

Journal of Materials Chemistry B

Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids†

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Detection of cell-surface sialic acids and photodynamic eradication of cancer cells using dye-modified polydopamine-coated gold nanobipyramids

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