Cancer cell membrane-coated nanogels as a redox/pH dual-responsive drug carrier for tumor-targeted therapy

Weide Xu; Jilong Wang; Qinghua Li; Chenghu Wu; Lingling Wu; Kaiqiang Li; Qin Li; Qing Han; Jingjing Zhu; Yongheng Bai; Junjie Deng; Jianxin Lyu; Zhen Wang

doi:10.1039/D1TB00788B

Cancer cell membrane-coated nanogels as a redox/pH dual-responsive drug carrier for tumor-targeted therapy

Weide Xu,^ab Jilong Wang,^c Qinghua Li,^c Chenghu Wu,^c Lingling Wu,^abd Kaiqiang Li,^ad Qin Li,^b Qing Han,^b Jingjing Zhu,^b Yongheng Bai,^e Junjie Deng,

*^cf Jianxin Lyu*^ab and Zhen Wang*^ab

Author affiliations

* Corresponding authors

^a Research Center of Blood Transfusion Medicine, Ministry of Education Key Laboratory of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China

^b School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China

^c Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China

^d Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China

^e Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

^f Oujiang Laboratory, Wenzhou, Zhejiang 325000, China

Abstract

Nanocarriers have shown great advantages in increasing the efficiency of drug delivery and reducing drug side effects. However, their lack of targeting and on-demand drug release abilities will seriously limit their clinical application. Herein, we report tumor cell membrane coated nanogels (NGs) with redox/pH dual-responsive behavior for enhanced tumor chemotherapy. The cell membrane coating improves the tumor targeting efficiency, and stimuli-responsive drug release enhances the therapeutic effects. These NGs are well dispersed in PBS with an average size of 109.1 ± 5.2 nm and a narrow polydispersity index of 0.12. Both in vitro and in vivo studies indicate that these NGs can responsively release the therapeutic drug DOX under acidic conditions or high GSH concentrations and effectively inhibit tumor growth. Based on the results, this nanogel shows promise as a platform for tumor-targeted chemotherapy for future clinical translation.

Journal of Materials Chemistry B

Cancer cell membrane-coated nanogels as a redox/pH dual-responsive drug carrier for tumor-targeted therapy

Abstract

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Cancer cell membrane-coated nanogels as a redox/pH dual-responsive drug carrier for tumor-targeted therapy

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