Issue 19, 2021

Palladium(ii)-catalyzed aerobic oxidative O–H/C–H isocyanide insertion: facile access to pyrrolo[2,1-c][1,4]benzoxazine derivatives

Abstract

Palladium-catalyzed aerobic oxidative cyclizations of substituted 2-(1H-pyrrol-1-yl)phenols with isocyanides via an O–H/C–H insertion cascade have been developed. This strategy provides facile access to pyrrolo[2,1-c][1,4]benzoxazine derivatives in good to excellent yields under an O2 atmosphere. The notable features of this protocol include its mild reaction conditions, atom-economy, and broad functional group tolerance.

Graphical abstract: Palladium(ii)-catalyzed aerobic oxidative O–H/C–H isocyanide insertion: facile access to pyrrolo[2,1-c][1,4]benzoxazine derivatives

Supplementary files

Article information

Article type
Paper
Submitted
01 Mar 2021
Accepted
08 Apr 2021
First published
15 Apr 2021

Org. Biomol. Chem., 2021,19, 4364-4368

Palladium(II)-catalyzed aerobic oxidative O–H/C–H isocyanide insertion: facile access to pyrrolo[2,1-c][1,4]benzoxazine derivatives

L. Luo, X. Chen, Z. Li, Y. Zhou, Y. Xiao and F. Chen, Org. Biomol. Chem., 2021, 19, 4364 DOI: 10.1039/D1OB00393C

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