Rapidly clearable MnCo2O4@PAA as novel nanotheranostic agents for T1/T2 bimodal MRI imaging-guided photothermal therapy

Ying Zhao; Yang Liu; Yinghui Wang; Bo Xu; Songtao Zhang; Jianhua Liu; Tianqi Zhang; Longhai Jin; Songyan Song; Hongjie Zhang

doi:10.1039/D1NR04067G

Rapidly clearable MnCo₂O₄@PAA as novel nanotheranostic agents for T₁/T₂ bimodal MRI imaging-guided photothermal therapy†

Ying Zhao,^ab Yang Liu,^ab Yinghui Wang,

*^a Bo Xu,^c Songtao Zhang,^a Jianhua Liu,

^d Tianqi Zhang,

^d Longhai Jin,

*^d Songyan Song

^a and Hongjie Zhang

*^abe

Author affiliations

* Corresponding authors

^a State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences, Changchun, Jilin, China
E-mail: yhwang@ciac.ac.cn, hongjie@ciac.ac.cn

^b School of Applied Chemistry and Engineering University of Science and Technology of China, Hefei 230026, China

^c The first hospital of Jilin University, Changchun 130021, China

^d Department of Radiology, The second hospital of Jilin University, Changchun 130041, China
E-mail: jinlonghai@jlu.edu.cn

^e Department of Chemistry, Tsinghua University, Beijing 100084, China

Abstract

Integrating multi-modal imaging and therapy functions into a nanoplatform has been recognized as a promising strategy for cancer theranostics with high accuracy and efficiency. However, there are still some challenges, such as the complicated synthesis process and instability. Herein, we successfully prepared clearable MnCo₂O₄ nanodots modified with polyacrylic acid (MnCo₂O₄@PAA) as nanoagents for T₁/T₂ bimodal MRI imaging-guided PTT. Owing to their intrinsic magnetic properties, single MnCo₂O₄@PAA nanomaterials can serve as contrasts for T₁/T₂ bimodal MRI, providing precise diagnotic information. Moreover, excellent absorption in the NIR biowindow endows MnCo₂O₄@PAA with good photothermal performance, and the ultrasmall size of MnCo₂O₄@PAA allows them to penetrate deeply into tumors, resulting in a good anticancer effect in vitro and in vivo. What is more, MnCo₂O₄@PAA can almost be completely cleared from mice at 7 d postinjection, implying their negligible long-term toxicity. These findings demonstrate that MnCo₂O₄@PAA are promising nanoagents for cancer diagnosis and treatment, which have great potential for clinical applications.

Nanoscale

Rapidly clearable MnCo₂O₄@PAA as novel nanotheranostic agents for T₁/T₂ bimodal MRI imaging-guided photothermal therapy†

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Rapidly clearable MnCo₂O₄@PAA as novel nanotheranostic agents for T₁/T₂ bimodal MRI imaging-guided photothermal therapy

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